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KMID : 0360220070480060789
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Journal of the Korean Ophthalmological Society
2007 Volume.48 No. 6 p.789 ~ p.798
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Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
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Yu Hyeong-Gon
Kang Se-Woong
Nam Woo-Ho
Koh Hyoung-Jun
Hyung Woo Kwak
Kwon Oh-Woong
Kim Si-Yeol
Kim In-Taek
Kim Ha-Kyoung
Kim Hyun-Woong
Roh Young-Jung
Moon Jun-Woong
Park Kyu-Hyung
Beyun Sek-Ho
Song Su-Jeong
Ahn Jae-Kyoun
Oum Boo-Sup
Oh Jae-Ryung
Yu Seung-Young
Yun Il-Han
Lee Sung-Chul
Lee Won-Ki
Lee Jeong-Hee
Lee Ji-Eun
Lee Tae-Gon
Choi Gwang-Ju
Ham Don-Il
Huh Kuhl
Chung Hum
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Abstract
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Purpose:To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients.
Methods:Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated.
Results:244 patients (244 eyes) were recruited (male: 60%, age: 67.7±9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient.
Conclusions:Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.
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KEYWORD
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Age-related macular degeneration, AMD, Choroidal neovascularization, CNV, Photodynamic therapy, PDT
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